Endocrine Abstracts

Integrins are cell-extracellular matrix adhesion molecules considered functionally related to the development of cancer metastasis. Starting from the dataset of mRNA-seq of papillary thyroid carcinoma (PTC) from the TCGA, we determined the expression of fibronectin 1 (FN1) and fibronectin-binding integrins in PTC. We then analyzed the association of the expression of these two genes with the driver genes, the stage of the disease and its outcome. 355 PTCs and 58 normal thyroid...

Introduction: The plasticizer Bisphenol A (BPA) is an endocrine disruptor with thyroid interfering activity. Obesity is a recognized risk factor for thyroid cancer. A recent study showed that subjects with BMI ≥ 25 are more prone to BPA-related thyroid disruption. To date, few and controversial experimental and epidemiological data provide weak evidence about a correlation between BPA exposure and thyroid cancer development. Aim of the present study was to assess a possi...

Introduction: GH deficiency (GHD) is a clinical disorder characterized by pathological short stature in the child, altered body composition, impaired psychological well-being and reduced quality of life. These alterations are almost always reversible after recombinant human GH (rhGH) administration, which is currently the only accepted treatment for the subjects with GHD. Secretory dysfunction is confirmed when GH peak does not reach the established cut-off in at least two dif...